Related Experiment Video
Updated: Jun 23, 2026

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
Published on: March 22, 2012
[Lymphomas and infections]
1Université Paris-Descartes, 75006 Paris, France. felipe.suarez@nck.aphp.fr
Abstract:
The incidence of non-Hodgkin lymphoma (NHL) has more than doubled in the last 20 years. The various mechanisms underlying malignant transformation of lymphoid cells all lead to an increased cellular proliferation and/or inhibition of apoptosis. Many infectious agents favor the development of NHL. Direct infection by lymphotropic viruses establishing a latent infection, such as the Epstein-Barr virus, interferes with cellular homeostasis and contribute to lymphoid transformation. Other infectious agents inducing chronic infections but unable to directly infect lymphocytes may also induce NHL. In this case, the sustained lymphoid proliferation induced by the persistent pathogen, increases the likelihood of malignant transformation, as exemplified by Helicobacter pylori-associated gastric MALT NHL. Identification of an associated infection in the setting of a NHL is important as eradication of the pathogen by antimicrobial therapy may lead to tumor regression.
Related Concept Videos
Lymphoid Cells and Tissues
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Disorders of Leukocytes
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Functions of the Lymphatic and Immune System
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
Secondary Lymphoid Organs
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Primary Lymphoid Organs
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Immunodeficiency Diseases
There are three main causes of immunodeficiency disorders...