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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Cerebral Edema ll: Pathophysiology01:22

Cerebral Edema ll: Pathophysiology

Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

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Updated: Jun 23, 2026

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
14:58

Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations

Published on: October 20, 2017

The evolution of cerebral revascularization surgery.

Melanie G Hayden1, Marco Lee, Raphael Guzman

  • 1Department of Neurosurgery, Stanford University Medical Center, Stanford, California 94305, USA.

Neurosurgical Focus
|May 5, 2009
PubMed
Summary

Cerebral bypass surgery evolved from early revascularization techniques pioneered by Alexis Carrel. Key studies and modern innovations continue to shape this neurosurgical procedure.

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Area of Science:

  • Neurosurgery
  • Vascular Surgery
  • Medical History

Background:

  • Alexis Carrel, a Nobel laureate, pioneered early revascularization surgery.
  • The evolution of cerebral bypass surgery traces back to the early 20th century.

Observation:

  • The Extracranial/Intracranial Bypass Study, initiated in 1977, was a cornerstone in developing bypass techniques.
  • Modern advancements include improved cerebral blood flow monitoring and microanastomosis techniques.

Findings:

  • The study reviews the historical development of cerebral revascularization surgery.
  • It evaluates recent innovations and ongoing trials in cerebral bypass surgery.

Implications:

  • Understanding the history informs current and future practices in cerebral bypass surgery.
  • Continued research and trials are crucial for advancing neurosurgical interventions for cerebrovascular diseases.