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Preparation, characterization, and antitumor activity of water-soluble aminoalkanol platinum(II) complexes
A R Khokhar1, Q Y Xu, R A Newman
1Department of Medical Oncology, University of Texas, M.D. Anderson Cancer Center, Houston 77030.
Journal of Inorganic Biochemistry
|July 1, 1991
Abstract:
A new series of highly water-soluble aminoalkanol platinum(II) complexes have been synthesized and characterized by elemental analysis, conductance, IR, and 195Pt NMR. Preliminary in vitro and in vivo screening tests for antitumor activities of these complexes against L1210 murine leukemia were performed. In general, these compounds were far less cytotoxic than cisplatin and possessed only a moderate degree of antitumor activity.