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Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation
Published on: February 29, 2020
Spinal congenital dermal sinus with dual ostia
Chang Sub Lee1, Ji Hoon Phi, Seung-Ki Kim
1Department of Neurosurgery, School of Medicine, Jeju National University, Jeju, Korea.
Journal of Neurosurgery. Pediatrics
|May 5, 2009
Summary
Multiple openings in congenital dermal sinus (CDS) are rare but can occur, especially with associated anomalies. A "zipping error" during early development may explain these atypical spinal formations.
Area of Science:
- Neuroscience
- Developmental Biology
- Medical Genetics
Background:
- Congenital dermal sinus (CDS) typically presents as a single midline tract.
- Multiple CDS tracts and ostia are exceptionally rare, with limited case reports.
Purpose of the Study:
- To analyze clinical features of patients with spinal CDS and multiple ostia.
- To propose a novel hypothesis for the pathogenesis of atypical CDS.
Main Methods:
- Retrospective review of clinical, radiological, and operative features.
- Inclusion of five patients with spinal CDS and multiple ostia.
Main Results:
- Observed various patterns of dual ostia (bilateral paramedian, paramedian/midline, unilateral paramedian at different levels).
- Internal tract endings varied; complete removal was achieved in all cases.
- Associated anomalies (lumbosacral lipoma, Currarino triad) were present in all patients; two had dermoid tumors.
Conclusions:
- Dual ostia in CDS can be unilateral or bilateral, particularly when associated anomalies are present.
- Atypical CDS with multiple ostia may result from aberrant neural tube closure, potentially a
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