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Updated: Jun 23, 2026
Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence
Published on: December 23, 2022
Transcatheter closure of large sized patent ductus arteriosus using the amplatzer duct occluder device
Muhammad Shabbir1, Khurram Akhtar, Maadullah
1Department of Cardiology, Armed Forces Institute of Cardiology/NIHD, Rawalpindi. shabbir_1441@yahoo.com
Insights
Transcatheter closure of large patent ductus arteriosus (PDA) using the Amplatzer Duct Occluder (ADO) is highly effective. This study shows the ADO device safely and efficiently closes large PDAs with excellent outcomes.
Area of Science:
- Cardiology
- Interventional Cardiology
- Pediatric Cardiology
Background:
- Patent ductus arteriosus (PDA) is a common congenital heart defect.
- Large PDAs often require intervention to prevent complications.
- Transcatheter closure offers a less invasive alternative to surgery.
Purpose of the Study:
- To evaluate the efficacy and safety of anterograde transcatheter closure of large PDAs.
- To assess the performance of the Amplatzer Duct Occluder (ADO) device in this patient group.
Main Methods:
- A case series of 100 patients with large PDAs (≥ 4.0 mm) treated between January 2005 and December 2007.
- Transcatheter closure was performed using the Amplatzer Duct Occluder (ADO) device.
- Aortography was used to confirm device position and assess for residual shunts post-procedure.
Main Results:
- Complete closure was achieved in 70% of patients immediately after the procedure.
- 26% had a trace shunt and 4% had a small residual shunt initially.
- No residual shunts were observed 24 hours post-procedure, indicating high efficacy.
Conclusions:
- The Amplatzer Duct Occluder (ADO) is a highly efficient prosthesis for PDA closure.
- Transcatheter closure with ADO is safe and effective, particularly for large PDAs.
- This minimally invasive approach offers excellent outcomes for patients with large PDAs.
Objective:
To assess the results of anterograde transcatheter closure of a large sized patent ductus arteriosus using the Amplatzer Duct Occluder (ADO) device.
Study Design:
A case series.
Place And Duration Of Study:
Department of Cardiology, Armed Forces Institute of Cardiology and National Institute of Heart Diseases, Rawalpindi, from January 2005 to December 2007.
Methodology:
All patients who underwent transcatheter closure of large sized PDA (> or = 4.0 mm), using the Amplatzer Duct Occluder (ADO) device, from January 2005 to December 2007, were included by convenient sampling technique. After the procedure, repeat aortogram was performed to confirm the appropriate position of the ADO and to evaluate for residual shunts.
Results:
A total of 100 patients had PDA diameter of > or = 4.00 mm. Mean age was 11.73 + 10.31 years and there were 37 males and 63 females. Mean PDA diameter was 6.011 + 2.078 mm. Forty-nine patients had type 'A', 19 had type 'B', 19 patients had type 'C', 5 had type 'D' and 8 patients had type 'E' PDA. Complete closure was achieved in 70 patients, 26 had trace shunt and 4 patients had small residual shunt immediately after the procedure. However, no patient had residual shunt 24 hours after the procedure.
Conclusion:
ADO is a highly efficient prosthesis that can be safely applied in most patients with PDA particularly in patients with large sized PDA.
