Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Traumatic brain injuries: structural changes.

J Cervós-Navarro1, J V Lafuente

  • 1Inst. of Neuropathology, Free University Berlin, Germany.

Journal of the Neurological Sciences
|July 1, 1991
PubMed
Summary

Brain contusions cause microscopic changes, including edema and axonal injury. The brain reacts with cellular changes and gliosis, potentially forming glial scars that may restore the blood-brain barrier.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Two-timepoint multidomain follow-up of post-COVID condition and ME/CFS: overlapping autonomic, small-fiber, and cognitive changes.

Journal of translational medicine·2026
Same author

Involvement of autoantibodies against G protein-coupled receptors in post-COVID condition and Chronic Fatigue Syndrome.

Scientific reports·2026
Same author

Dysautonomia and small fiber neuropathy in post-COVID condition and Chronic Fatigue Syndrome.

Journal of translational medicine·2023
Same author

The role of ketamine in major depressive disorders: Effects on parvalbumin-positive interneurons in hippocampus.

Experimental biology and medicine (Maywood, N.J.)·2023
Same author

Brain fog of post-COVID-19 condition and Chronic Fatigue Syndrome, same medical disorder?

Journal of translational medicine·2022
Same author

Correction to: Deleterious Effects of VEGFR2 and RET Inhibition in a Preclinical Model of Parkinson's Disease.

Molecular neurobiology·2018

Area of Science:

  • Neuroscience
  • Neuropathology
  • Traumatic Brain Injury

Background:

  • Brain injuries, such as contusions, lead to complex complications.
  • Understanding the microscopic, temporal evolution of brain injury is crucial for comprehending the damage and the brain's response.

Purpose of the Study:

  • To detail the microscopic temporal evolution of brain contusions.
  • To elucidate the brain's reaction to physical force-induced damage.

Main Methods:

  • Microscopic examination of brain tissue following contusion.
  • Observation of cellular and extracellular changes over time.

Main Results:

  • Early extracellular edema due to blood-brain barrier disruption, appearing spongy with vacuoles.
  • Neuronal changes include swelling, shrinkage, eosinophilia, and nuclear pyknosis, persisting for months.
  • Axonal changes like swelling and ballooning (diffuse axonal injury) occur early and can persist for years, with potential calcification.
  • Reactive gliosis begins around 7-10 days, with astrocytes increasing in number and fibrillary appearance, forming glial scars over months to years.

Conclusions:

  • Microscopic analysis reveals a dynamic temporal evolution of brain injury response.
  • Edema, neuronal, and axonal changes characterize early injury, followed by reactive gliosis and glial scar formation.
  • Reactive gliosis may play a role in restoring blood-brain barrier integrity in damaged areas.

Related Experiment Videos