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Updated: Jun 23, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis and therapeutic evaluation of pyridyl based novel mTOR inhibitors
Vijaykumar Deore1, Nilambari Yewalkar, Dimple Bhatia
1Department of Medicinal Chemistry, Piramal Life Sciences, 1-Nirlon Complex, Goregaon (E), Mumbai, India.
Abstract:
A series of novel cyanopyridyl based molecules (1-14) were designed, synthesized and probed for inhibition of mammalian target of rapamycin (mTOR) activity. Compound 14 was found to be a potent inhibitor of mTOR activity as assessed by enzyme-linked immunoassays and Western blot analysis. Most importantly, systemic application (intraperitoneal; ip) of compound 14 significantly suppressed macroscopic and histological abnormalities associated with chemically-induced murine colitis.
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