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Updated: Jun 23, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Stimulation of Notch Signaling in Mouse Osteoclast Precursors

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NKAP is a transcriptional repressor of notch signaling and is required for T cell development

Anthony G Pajerowski1, Chau Nguyen, Haig Aghajanian

  • 1Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Immunity
|May 5, 2009
PubMed

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Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

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Role Of Notch Signalling In Intestinal Stem Cell Renewal

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NF-kB-dependent Signaling Pathway02:26

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