Related Experiment Video
Updated: Jun 23, 2026

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
Published on: June 15, 2019
The effect of hyaluronic acid on brushite cement cohesion
M H Alkhraisat1, C Rueda, F T Mariño
1Departamento de Química-Física II, Facultad de Farmacia, UCM, 28040 Madrid, Spain. mkhresat@farm.ucm.es
Abstract:
The improvement of calcium phosphate cement (CPC) cohesion is essential for its application in highly blood perfused regions. This study reports the effectiveness of hyaluronic acids of different molecular weights in the enhancement of brushite cement cohesion. The cement was prepared using a powder phase composed of a mixture of beta-tricalcium phosphate and monocalcium phosphate monohydrate, whereas the liquid phase was formed by 0.5M citric acid solution modified by the addition of hyaluronic acid of different molecular weights. It was found that medium and high molecular weight hyaluronic acid enhances the cement cohesion and scarcely affects the cement mechanical properties. However, concentrations >0.5% (w/v) were less efficient to prevent the cement disintegration. It is concluded that hyaluronic acid could be applied efficiently to reduce brushite cement disintegration.
Related Concept Videos
Hydration of Cement
Porosity in Cement Paste
The balance of water to cement in the mix is critical—it...
Strength and Heat of Hydration
The heat of hydration for each cement compound is significant; for instance, tricalcium aluminate (C3A) and...
Bonding and Strength of Aggregate
Alkali Aggregate Reaction in Concrete
Transition Zone