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Updated: Jun 23, 2026
09:33
Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
Published on: February 7, 2018
Metabolic syndrome and oxidative stress
Katsuyuki Ando1, Toshiro Fujita
1Department of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, Tokyo 113-8655, Japan.
Free Radical Biology & Medicine
|May 5, 2009
Summary
Reactive oxygen species (ROS) link metabolic syndrome and salt-sensitive hypertension, worsening cardiovascular risk. Managing ROS is key to addressing these interconnected health threats exacerbated by obesity and high salt intake.
Area of Science:
- Cardiovascular Science
- Metabolic Disorders
- Oxidative Stress Research
Background:
- Metabolic syndrome, linked to obesity, increases cardiovascular risk.
- Metabolic syndrome is associated with increased reactive oxygen species (ROS) production.
- ROS play a critical role in the interplay between metabolic syndrome and salt-sensitive hypertension.
Purpose of the Study:
- To elucidate the role of ROS in the development and progression of metabolic syndrome and associated cardiovascular disease (CVD).
- To understand how ROS mediate the relationship between metabolic syndrome, salt-sensitive hypertension, and CVD.
Main Methods:
- Review of existing literature on metabolic syndrome, ROS, hypertension, and CVD.
- Analysis of pathways involving ROS, insulin resistance, mineralocorticoid receptors (MRs), and the sympathetic nervous system.
Main Results:
- ROS induce insulin resistance, a key factor in metabolic syndrome progression.
- Salt-sensitive hypertension stimulates ROS production, promoting metabolic syndrome.
- ROS activate MRs and the sympathetic nervous system, contributing to metabolic syndrome and salt-sensitive hypertension.
Conclusions:
- ROS are central mediators in the progression of metabolic syndrome and its associated CVD, especially with high salt intake.
- Targeting ROS may offer a therapeutic strategy for metabolic syndrome and salt-sensitive hypertension.
- The combined impact of obesity, excess salt, and ROS exacerbates cardiovascular risk in metabolic syndrome.
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