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A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
Published on: June 8, 2014
Osteonecrosis associated with short-term oral administration of bisphosphonate
Yuki Takagi1, Yasunori Sumi, Atsushi Harada
1Division of Oral and Dental Surgery, Department of Advanced Medicine, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan.
Abstract:
Orally administered bisphosphonates are generally considered a first-line medication for treatment of osteoporosis. As a side effect of bisphosphonates, osteonecrosis of the jaws (ONJ) has been reported worldwide. Most reports of osteonecrosis are attributed to the use of bisphosphonates administered intravenously for the treatment of bone disorders such as multiple myeloma. However, osteonecrosis has also been diagnosed in patients receiving oral bisphosphonates. The management of a patient with spontaneous removable partial denture prosthesis-related ONJ associated with short-term oral administration of bisphosphonate is described.
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