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[Rhino-orbito-cerebral mucormycosis in the diabetic: a better known pathology in Tunisia]

S Anane1, E Kaouech, S Belhadj

  • 1Service de parasitologie-mycologie, CHU la Rabta, Tunis, Tunisie. emna.chaker@rns.tn

Annales De Biologie Clinique
|May 5, 2009
PubMed

Insights

Rhino-orbito-cerebral mucormycosis is a severe fungal infection primarily affecting diabetic patients. Early diagnosis and surgical intervention are crucial for improving survival rates in this aggressive disease.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Ophthalmology

Context:

  • Rhino-orbito-cerebral mucormycosis (ROCM) is a rare but life-threatening fungal infection.
  • Diabetic ketoacidosis is a significant risk factor for ROCM.
  • This study reviews ROCM cases over a 16-year period.

Purpose:

  • To analyze the clinical characteristics, diagnosis, treatment, and outcomes of ROCM patients.
  • To identify factors contributing to the high mortality rate.

Summary:

  • A retrospective study of 17 ROCM patients (8 male, 9 female) diagnosed between 1992 and 2007.
  • All patients had diabetes mellitus; 8 had diabetic ketoacidosis. Facial necrosis and ophthalmic symptoms were common.
  • Rhizopus oryzae was identified in 12 cases. Treatment involved amphotericin B and surgery in only 7 patients.
  • High mortality (65%) was linked to delayed diagnosis and lack of surgical treatment.

Impact:

  • Highlights the critical need for prompt diagnosis and aggressive management, including surgery, for ROCM.
  • Emphasizes the importance of glycemic control in diabetic patients to prevent mucormycosis.
  • Informs clinical practice regarding the management of this devastating infection.

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