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Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
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A novel mode of FoxM1 regulation: positive auto-regulatory loop

Marianna Halasi1, Andrei L Gartel

  • 1Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.

Cell Cycle (Georgetown, Tex.)
|May 5, 2009
PubMed

Insights

The oncogenic transcription factor FoxM1 is a cancer target. Thiazole antibiotics inhibit FoxM1, revealing a novel positive auto-regulation mechanism for this key cancer-promoting factor.

Area of Science:

  • Molecular biology
  • Cancer research
  • Drug discovery

Background:

  • The transcription factor FoxM1 is oncogenic and overexpressed in many human cancers.
  • FoxM1 is a validated therapeutic target for cancer treatment.

Purpose of the Study:

  • To investigate the mechanism of action of FoxM1 inhibitors.
  • To identify novel therapeutic strategies targeting FoxM1.

Main Methods:

  • Screening for FoxM1 inhibitors.
  • Investigating the mechanism of action of identified inhibitors.

Main Results:

  • Thiazole antibiotics were identified as potent inhibitors of FoxM1.
  • A novel positive auto-regulation mechanism of FoxM1 was discovered.

Conclusions:

  • FoxM1 inhibitors, such as thiazole antibiotics, represent a promising therapeutic avenue.
  • Understanding FoxM1 auto-regulation may lead to more effective cancer therapies.

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