Can infections protect against autoimmunity?

It has often been suggested that autoimmune diseases are initiated by certain infectious agents that mimic self-antigens or polyclonally activated autoreactive lymphocytes. An alternative, and not necessarily mutually exclusive, hypothesis that some infections might inhibit the onset of some autoimmune conditions has more recently been explored. In this review, the evidence suggesting that the current rise in the incidence of some autoimmune diseases is attributable to a decrease in the incidence of exposure to certain infections will be discussed.

Studies using animal models have shown that some infectious agents or products derived from them have the potential to inhibit the onset of autoimmunity. These studies have led to the suggestion that human autoimmune or allergic diseases might be alleviated by the use of microbial products. There are some data that would support such an observation.

The incidence of some autoimmune diseases has increased dramatically in recent years in the developed world. Many autoimmune diseases are governed by both genetic and environmental factors. Our immune system has coevolved with infectious agents. There have been marked changes in the exposure to certain infectious agents over the last 70 years. It has been proposed that certain infections of historical importance might inhibit the development of autoimmune disorder. This review highlights studies addressing the ways in which infectious agents might inhibit onset of autoimmunity, and how this might lead to the development of novel therapeutic approaches.