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Intracranial Aspergillus infection associated with an amyloid tumor and lymphoma

B Dhamija1, M F Hassan, H Thambinayagam

  • 1South West Neurosurgical Centre, Derriford Hospital, Derriford Road, Plymouth, United Kingdom.

Skull Base : Official Journal of North American Skull Base Society ... [Et Al.]
|May 5, 2009
PubMed

Insights

Intracranial aspergillus infection is rare but potentially fatal. Early diagnosis in immunocompromised patients is crucial, as illustrated by a case with synchronous fungal infection, amyloid tumor, and lymphoma.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Oncology

Background:

  • Intracranial aspergillus infection is an uncommon but serious condition.
  • A high index of clinical suspicion and early diagnosis are vital for patient survival.

Observation:

  • A patient presented with visual disturbance and facial paresthesia.
  • Radiological diagnosis suggested meningioma.
  • Histopathology revealed a co-occurring amyloid tumor, aspergillus infection, and lymphoma.

Findings:

  • Synchronous intracranial aspergillus infection, amyloid tumor, and lymphoma were identified at the same site.
  • This complex presentation highlights diagnostic challenges in neuro-oncology and neuro-infectious diseases.

Implications:

  • Consider intracranial aspergillus infection in immunocompromised patients presenting with neurological symptoms.
  • Utilize a combination of neurological and thoracic imaging alongside histopathology for accurate diagnosis.
  • Prompt diagnosis and treatment are critical for improving outcomes in such rare cases.
Keywords:
Intracranial aspergillosisamyloidlymphomameningiomaskull base

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