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Published on: November 21, 2013
Longitudinal neurocognitive outcome in an adolescent with Hurler-Scheie syndrome
T David Elkin1, Gail Megason, Anita Robinson
1The University of Mississippi Medical Center, Departments of Psychiatry. delkin@psychiatry.umsmed.edu
Abstract:
An adolescent with Hurler-Scheie syndrome is reported. This now 15 year-old-young woman was initially diagnosed at age 4. She was assessed for neurocognitive functioning at ages 5, 13, and 15 years. Results show a significant decline in intellectual functioning from the superior range to the average range from age 5 to age 13, and then no change from age 13 to age 15. The relationship between Hurler-Scheie syndrome, premorbid intellectual functioning, and cognitive-behavioral interventions are discussed in light of the longitudinal neurocognitive effects of this disease.
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