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Updated: Jun 23, 2026
An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
Recalcitrant granulomatous sclerouveitis in a patient with granulomatous ANCA-associated vasculitis
Grace Levy-Clarke1, Xiaoyan Ding, Sapna Gangaputra
1St. Luke's Cataract and Laser Center, St. Petersburg, Florida 33702, USA. gclarke@stlukeseye.com
Purpose:
To report an unusual case of granulomatous sclerochoroiditis.
Design:
Interventional case report.
Methods:
A patient with ANCA-associated granulomatous vasculitis presented with nodular necrotizing scleritis, which was recalcitrant to multiple systemic immunosuppressive therapies and progressed to a blind painful eye, which was enucleated.
Results:
Histopathology revealed extensive occlusive vasculitis, diffuse T- and B- cellular infiltration, and lymphoid granulomatous formation. Enhanced MHC class II antigens, adhesion molecules, and Fas (CD95) and FasL (CD95L) were detected in the lesion.
Conclusion:
Granulomatous sclerochoroiditis with aggressive immune reaction can be a complication of ANCA-associated granulomatous vasculitis.
