Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Enterococcus: an old pathogen with new tricks.

L A Haglund1, D J Flournoy, M S Gilmore

  • 1Department of Infectious Diseases, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City.

The Journal of the Oklahoma State Medical Association
|July 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct Mineralogy and Age of Individual Lava Flows in Atla Regio, Venus Derived From Magellan Radar Emissivity.

Journal of geophysical research. Planets·2021
Same author

Low radar emissivity signatures on Venus volcanoes and coronae: New insights on relative composition and age.

Icarus·2021
Same author

Glutathione S-transferase alpha 4 induction by activator protein 1 in colorectal cancer.

Oncogene·2016
Same author

Virulence factors in vancomycin-resistant and vancomycin- susceptible Enterococcus faecalis from Brazil.

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]·2013
Same author

Multilocus sequence typing and analysis of putative virulence factors in vancomycin-resistant and vancomycin-sensitive Enterococcus faecium isolates from Brazil.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2006
Same author

The selective advantage of microbial fratricide.

Proceedings of the National Academy of Sciences of the United States of America·2005

High-level aminoglycoside resistance in enterococci is common in Oklahoma, particularly gentamicin resistance in blood isolates. Routine screening is recommended for serious infections to guide treatment effectively.

Area of Science:

  • Clinical Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Enterococci are significant nosocomial pathogens.
  • High-level aminoglycoside resistance (HLAR) can compromise treatment efficacy.
  • Vancomycin resistance and beta-lactamase production are other concerning enterococcal traits.

Purpose of the Study:

  • To determine the prevalence of HLAR, vancomycin resistance, beta-lactamase production, and hemolysin production among clinical enterococcal isolates.
  • To assess the co-occurrence of HLAR and hemolysin production in blood isolates.
  • To evaluate the correlation between antibiotic treatment and patient outcomes for enterococcal bacteremia.

Main Methods:

  • Screening of clinical enterococcal isolates for resistance phenotypes.

Related Experiment Videos

  • Phenotypic testing for high-level aminoglycoside resistance (gentamicin, kanamycin, streptomycin).
  • Testing for vancomycin resistance, beta-lactamase production, and hemolysin production.
  • Review of patient charts to assess treatment and outcomes.

    • Main Results:

    • 55% of isolates exhibited HLAR (gentamicin, kanamycin, or streptomycin).
    • 59% of HLAR isolates showed high-level gentamicin resistance; 21% of all isolates were hemolytic.
    • 46% of blood isolates with HLAR also produced hemolysin. No vancomycin-resistant or beta-lactamase-producing isolates were identified.
    • No correlation found between antibiotic treatment and outcomes for enterococcal bacteremia.

    Conclusions:

    • Enterococci with multiple HLAR are prevalent at this medical center.
    • Vancomycin resistance and beta-lactamase production were not detected in this study.
    • Routine screening for HLAR in enterococci from serious infections is crucial for clinical microbiology laboratories.