Related Experiment Video
Updated: Jun 23, 2026
Acquisition and Semi-Automated Analysis of Respiratory Muscle Surface Electromyography
Published on: January 24, 2025
Validation of ApneaLink as screening device for Cheyne-Stokes respiration
Gerhard Weinreich1, Jeff Armitstead, Volker Töpfer
1Ruhrlandklinik, Department of Respiratory Medicine, Faculty of Medicine, University of Duisburg-Essen, Essen, Germany. gerhard.weinreich@uni-due.de
Study Objectives:
Polysomnography (PSG) is the gold standard in diagnosing sleep disordered breathing (SDB). Diagnostic analysis of SDB is time-consuming and labor-intensive and entails long waiting lists for patients. The aim of this study was to assess the validity of a flow-based screening classifier as an automated diagnostic test for Cheyne-Stokes respiration (CSR).
Setting:
Sleep laboratory.
Participants:
70 study subjects (28 with obstructive sleep apnea [OSA], 20 with CSR, 11 with CSR+OSA and 11 without SDB).
Measurements:
The nasal cannula flow signal was analyzed by ApneaLink (ResMed, Sydney, Australia), based on a classifier algorithm using pattern recognition. In a simultaneous PSG, results were compared with manual scoring of respiratory events by certified sleep experts.
Results:
For detecting CSR we obtained a sensitivity of 87.1% (95% confidence interval 75.3% to 98.9%), a specificity of 94.9% (95% confidence interval 87.9% to 100%), a positive likelihood ratio of 17.0, and a negative likelihood ratio of 0.14. The area under the curve (AUC) of the according receiver operating characteristic (ROC) curve was 93.4%. This resulted in an accuracy of 91.4% for identifying CSR.
Conclusion:
In this study we demonstrated that the screening classifier was able to detect CSR with high diagnostic accuracy. Hence, ApneaLink equipped with CSR classifier is an appropriate screening tool which may help to prioritize patients with CSR for PSG.
Related Concept Videos
01:30Alterations in Respiration II
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes include...
01:30Assessment of Airway, Skin Color, and Use of Accessory Muscles
Introduction
The initial evaluation of a patient's respiratory system...
01:27Physical Assessment of the Respiratory Tract II: Inspection
Chest Configuration
The chest configuration can...
01:23Assessment of Respiration
Subjective Assessment: Nurses interview the patient to gather information directly during the subjective assessment. It includes questions about the individual's medical history, medications, and symptoms, focusing on past respiratory conditions like asthma or COPD,...
01:20Assessment of Ventilation I: Respiratory Rate
A Ventilation assessment is critical for monitoring a patient's health status. Respiration, one of the most accessible vital signs, provides insights into the function of numerous body systems and can indicate serious health issues, such as brainstem injuries from head trauma.
Critical Guidelines for Assessing Ventilation:
01:19Respiratory Assessment: Purpose and Indications
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...