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Updated: Jun 23, 2026
Generation of Monoclonal Antibodies Against Natural Products
Published on: April 6, 2019
Lignans with anti-HIV activity from Schisandra propinqua var. sinensis
Xiao-Nian Li1, Jian-Xin Pu, Xue Du
1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People's Republic of China.
Abstract:
Fourteen new lignans, tiegusanins A-N (1-14), together with 13 known compounds were isolated from the aerial parts of Schisandra propinqua var. sinensis. The structures and absolute configurations of 1-13 were established using a combination of spectroscopic techniques. Compound 14 was obtained as a racemate. When evaluated for inhibitory activity against HIV-1, tiegusanin G (7) showed anti-HIV-1 activity with an EC(50) value of 7.9 microM and a therapeutic index (TI) of more than 25.