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Updated: Jun 23, 2026
Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
Published on: August 13, 2019
Biomechanical and histomorphometric characterizations of osseointegration during mini-screw healing in rabbit tibiae
Jing Wu1, Yu-Xing Bai, Bang-Kang Wang
1Department of Orthodontics, Capital Medical University, School of Stomatology, Chongwen district, Beijing, Beijing 100050, China. crystalwupaper@gmail.com
Objective:
To evaluate effects of different healing times on integration of titanium mini-screws and bones under unloaded conditions.
Materials And Methods:
Biomechanical stability measurements and histomorphometric observations were performed in a rabbit tibia model after different healing times: 0 (immediate) and 1, 2, 4, and 8 weeks.
Results:
Biomechanical stability and both maximum torque and maximum pullout load increased with healing time but increased significantly only after 4 weeks. Maximum torque and maximum pullout load both significantly correlated with healing time and with each other. Similarly, histomorphometric analyses showed that new bone formation increased with healing time but increased dramatically only after 4 weeks. The data may provide guidance for determining optimal implant plans in clinical practice.
Conclusion:
Mini-screw healing is a continuous process, and week 4 is a critical time point in this process.
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