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Updated: Jun 23, 2026
Midface Hypoplasia and Cranial Base Morphology in Syndromic Craniosynostosis: A Comparative Analysis Study Using a Predictive Regression Model
Published on: November 4, 2025
Third molar agenesis and craniofacial morphology
María José Sánchez1, Ascensión Vicente, Luis Alberto Bravo
1Docent Unit of Orthodontics, Dental Clinic, University of Murcia, Murcia, Spain.
Objective:
To test the null hypothesis that agenesis of wisdom teeth is not related with any particular craniofacial morphology.
Materials And Methods:
Ninety-seven patients (aged 13-19 years) were selected and divided into three groups: (1) bilateral agenesis of maxillary third molars, (2) bilateral agenesis of mandibular third molars, and (3) control group without agenesis. Presence or absence of third molars was determined using ortopantomographs. Cephalometric analysis was carried out from lateral teleradiographs, which included linear, angular, and proportional measurements. When data obtained were distributed normally it was analyzed by means of single-factor variance analysis and the Scheffé test (P < .05). When data did not show normality, the Kruskal-Wallis test (P < .05) and the Mann-Whitney test were applied using Bonferroni correction (P < .017). Multivariance discrimination analysis was also carried out.
Results:
Values obtained for the mandibular plain of Groups 1 and 2 were significantly lower than those of the Control Group (P =.00 and P =.00, respectively). For Group 2 lower face height was significantly less than for the control group (P =.01), whilst the mandibular arch and the articular angle were significantly greater than in the Control Group (P =.000 and P = .02, respectively). Multivariance discrimination analysis obtained a correct classification in 58.8% of cases.
Conclusion:
The hypothesis is rejected. Agenesis of the maxillary third molars was related to a reduced mandibular plane angle. Patients with agenesis of the mandibular third molars showed a diminished lower third and a mandibular morphology characteristic of the brachyfacial pattern.
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