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Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Snap Chip for Cross-reactivity-free and Spotter-free Multiplexed Sandwich Immunoassays
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Living-cell microarrays.

Martin L Yarmush1, Kevin R King

  • 1Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, Massachusetts 02139, USA. ireis@sbi.org

Annual Review of Biomedical Engineering
|May 6, 2009
PubMed
Summary
This summary is machine-generated.

Living-cell microarrays enable high-throughput screening of chemical and genomic libraries to understand cellular responses. These advanced assays investigate cellular microenvironments, aiding in disease gene discovery and drug development.

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Last Updated: Jun 23, 2026

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Published on: November 13, 2017

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Area of Science:

  • Cell Biology
  • Biotechnology
  • Genomics

Background:

  • Living cells exhibit complex behaviors and responses to stimuli.
  • Traditional assays have limitations in high-throughput analysis.
  • Living-cell microarrays integrate microtiter plates, spotting, microfabrication, and microfluidics.

Purpose of the Study:

  • To develop high-throughput living-cell assays for large-scale screening.
  • To systematically investigate the cellular microenvironment.
  • To identify genetic factors in diseases and discover cellular function modulators.

Main Methods:

  • Utilizing microtiter plates for high-density spotting.
  • Employing microfabrication and microfluidics for assay development.
  • Applying experimental stimuli and measuring cellular responses.

Main Results:

  • Development of living-cell microarrays for two primary applications.
  • Demonstrated potential for screening large chemical and genomic libraries.
  • Enabled systematic investigation of local cellular microenvironments.

Conclusions:

  • Living-cell microarrays offer powerful platforms for biological research.
  • These assays accelerate the identification of disease-related genes.
  • They provide new avenues for discovering modulators of cellular function and understanding cell-environment interactions.