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Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen
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Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

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Anticancer activity of Panax notoginseng extract 20(S)-25-OCH3-PPD: Targetting beta-catenin signalling

Xiuli Bi1, Yuqing Zhao, Wenfeng Fang

  • 1Department of Pathology, University of Illinois at Chicago, Chicago, Illinois 60612, USA.

Clinical and Experimental Pharmacology & Physiology
|May 6, 2009
PubMed

Insights

A novel compound, PPD25, derived from Panax notoginseng, effectively inhibits cancer cell growth and promotes apoptosis. It targets the Wnt/beta-catenin pathway, showing potential for cancer prevention and therapy.

Area of Science:

  • Natural Products Chemistry
  • Molecular Biology
  • Cancer Research

Background:

  • The Wnt/beta-catenin pathway is crucial in cancer development.
  • Targeting this pathway offers potential for cancer prevention and treatment.
  • Natural products are a source of novel anticancer agents.

Purpose of the Study:

  • To investigate the anticancer activity of dammarane-type triterpene sapogenin (20(S)-25-OCH3-PPD; PPD25).
  • To evaluate PPD25's effects on colon and lung cancer cell lines.
  • To elucidate the molecular mechanisms underlying PPD25's anticancer effects.

Main Methods:

  • Anticancer activity was assessed in four cancer cell lines (3 colon, 1 lung).
  • Inhibition of cell proliferation and induction of apoptosis were measured.
  • Western blotting and reporter assays were used to study pathway modulation.

Main Results:

  • PPD25 significantly inhibited proliferation and induced apoptosis in all tested cancer cell lines.
  • PPD25 reduced the expression of beta-catenin and its downstream targets (c-myc, cyclin D1, cdk4, TCF-4).
  • PPD25 suppressed beta-catenin/TCF transcriptional activity.

Conclusions:

  • PPD25 exhibits anticancer properties by targeting the Wnt/beta-catenin signaling pathway.
  • PPD25 demonstrates potential as a chemotherapeutic or chemopreventive agent for colon and lung cancers.
  • Further research into PPD25 is warranted for cancer treatment strategies.

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