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Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

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Gross Anatomy of the Liver01:17

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Related Experiment Video

Updated: Jun 23, 2026

Measurement of Liver Stiffness Using Atomic Force Microscopy Coupled with Polarization Microscopy
10:10

Measurement of Liver Stiffness Using Atomic Force Microscopy Coupled with Polarization Microscopy

Published on: July 20, 2022

Variability in liver stiffness values from different intercostal spaces.

Seung Up Kim1, Ja Kyung Kim, Jun Yong Park

  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

Liver International : Official Journal of the International Association for the Study of the Liver
|May 6, 2009
PubMed
Summary

Liver stiffness measurement (LSM) accurately predicts significant fibrosis and cirrhosis in hepatitis B virus-related chronic liver disease. The measurement site, including intercostal spaces (ICS), does not impact its predictive accuracy compared to liver biopsy (LB).

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Last Updated: Jun 23, 2026

Measurement of Liver Stiffness Using Atomic Force Microscopy Coupled with Polarization Microscopy
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Published on: July 20, 2022

A Three-Dimensional Digital Model for Early Diagnosis of Hepatic Fibrosis Based on Magnetic Resonance Elastography
06:09

A Three-Dimensional Digital Model for Early Diagnosis of Hepatic Fibrosis Based on Magnetic Resonance Elastography

Published on: July 21, 2023

Area of Science:

  • Hepatology
  • Gastroenterology
  • Medical Imaging

Background:

  • Hepatitis B virus (HBV)-related chronic liver disease (CLD) is a global health concern.
  • Accurate staging of liver fibrosis is crucial for patient management and treatment decisions.
  • Liver stiffness measurement (LSM) is a non-invasive method to assess liver fibrosis.

Purpose of the Study:

  • To evaluate the variability of LSM values obtained from different intercostal spaces (ICS).
  • To determine if LSM predicts significant fibrosis (F2-4) and cirrhosis more accurately when performed at the same site as liver biopsy (LB).

Main Methods:

  • 91 patients with HBV-related CLD underwent both liver biopsy (LB) and LSM.
  • LSM was performed at the fifth, sixth, and seventh ICS.
  • LSM values were compared based on measurement site and correlation with LB findings.

Main Results:

  • Mean LSM values were similar across the fifth (11.6 kPa), sixth (11.1 kPa), and seventh (10.9 kPa) ICS.
  • No significant difference in LSM values was found between ICS and the same site as LB (11.0 kPa).
  • LSM demonstrated high accuracy in predicting significant fibrosis and cirrhosis, with overlapping confidence intervals regardless of the measurement site.

Conclusions:

  • LSM at the fifth, sixth, or seventh ICS reliably predicts significant fibrosis and cirrhosis in HBV-related CLD.
  • The specific intercostal space used for LSM does not affect its diagnostic accuracy.
  • LSM is a valuable non-invasive tool for staging liver fibrosis in HBV-related CLD, irrespective of its correlation with the liver biopsy site.