Related Experiment Video
Updated: Jun 23, 2026

07:16
Three-Dimensional Imaging of Tumor-Bearing Tissue Using the Iterative Bleaching Extends Multiplexity Approach
Published on: April 25, 2025
Imaging features of primary extranodal lymphomas.
S C Chua1, F I Rozalli, S R O'Connor
1Department of Nuclear Medicine, PET, and Radiology, The Royal Marsden NHS Foundation Trust, Sutton, Surrey, UK. sue.chua@rmh.nhs.uk
Clinical Radiology
|May 6, 2009
Summary
Extranodal lymphomas, tumors outside lymph nodes, present unique imaging features. This review details their radiological appearances based on current World Health Organization classifications.
Area of Science:
- Radiology
- Oncology
- Pathology
Background:
- Lymphomas typically affect lymph nodes, but up to 40% originate extranodally.
- Extranodal lymphomas exhibit distinct pathological, radiological, and clinical characteristics.
- Accurate radiological descriptions are challenged by evolving lymphoma classifications.
Purpose of the Study:
- To review the radiological appearances of primary extranodal lymphomas.
- To categorize these appearances according to the current World Health Organization (WHO) lymphoma classification.
- To highlight the diagnostic value of imaging in identifying extranodal lymphoma subtypes.
Main Methods:
- Comprehensive literature review of radiological imaging studies.
- Analysis of imaging findings across various extranodal sites.
- Correlation of radiological features with current WHO lymphoma classifications.
Main Results:
- Extranodal lymphomas demonstrate diverse radiological features.
- Specific imaging patterns can suggest lymphoma diagnosis and subtype.
- Radiological findings vary depending on the extranodal site and lymphoma subtype.
Conclusions:
- Radiological assessment is crucial for diagnosing and subtyping extranodal lymphomas.
- Understanding current WHO classifications aids in interpreting imaging findings.
- This review provides a framework for recognizing extranodal lymphoma on medical imaging.
Related Concept Videos
Primary Lymphoid Organs
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Detailed Structure and Function of Lymph Nodes
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
Lymphoid Cells and Tissues
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...