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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
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Related Experiment Video

Updated: Jun 23, 2026

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
09:44

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

Update on genetics in inflammatory disease.

Casper G Noomen1, Daniel W Hommes, Herma H Fidder

  • 1Department of Gastroenterology and Hepatology, Leiden University Medical Center, C4-12 Leiden, the Netherlands. c.g.noomen@lumc.nl

Best Practice & Research. Clinical Gastroenterology
|May 6, 2009
PubMed
Summary
This summary is machine-generated.

Inflammatory bowel disease (IBD) involves immune system dysfunction and gut factors. Recent genetic studies, including genome-wide association studies (GWAS), reveal over 30 new gene regions linked to IBD pathogenesis.

Related Experiment Videos

Last Updated: Jun 23, 2026

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
09:44

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis

Published on: October 14, 2025

Area of Science:

  • Immunology
  • Gastroenterology
  • Genetics

Background:

  • Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, arises from complex immune system dysregulation interacting with gut microbiota.
  • The precise etiology of IBD remains elusive, necessitating ongoing research into its immunopathogenesis.

Purpose of the Study:

  • To review recent advancements in understanding IBD genetics and immunobiology.
  • To highlight the role of genetic factors and immune system interactions in maintaining gut homeostasis and driving IBD pathogenesis.

Main Methods:

  • Analysis of accumulating data, including genome-wide association studies (GWAS).
  • Review of past and recent findings on IBD genetics and immunobiology.

Main Results:

  • Genome-wide association studies (GWAS) have confirmed previously identified IBD-associated genes like NOD2 and the IBD5 locus.
  • Over 30 novel genetic loci associated with IBD have been identified.
  • Strong associations between Crohn's disease and variants in IL23R and ATG16L1 genes have been consistently replicated.

Conclusions:

  • Genetic research, particularly GWAS, significantly enhances understanding of IBD immunopathogenesis.
  • The immune system's interaction with intestinal flora is crucial in the development of inflammatory bowel disease.