Insulin-like growth factor-binding protein-3 in breast cancer: analysis with tissue microarray
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Shyr-Ming Sheen-Chen1, Hao Zhang, Chao-Cheng Huang
1Department of Surgery, Kaohsiung Medical Center, Kaohsiung Hsien, Taiwan, Republic of China. smsheen@yahoo.com
Background:
IGFBP-3 has been reported to be growth-stimulatory. The creation of tissue microarray (TMA) allows for the rapid immunohistochemical analysis of thousands of tissue samples in a parallel fashion. This study was designed with the application of TMA to analyze the IGFBP-3 status in breast cancer with the hope to elucidate the possible relationship between IGFBP-3 expression and breast cancer biology.
Materials And Methods:
Archival tissue specimens from 97 patients with primary invasive breast cancer were selected. The IGFBP-3 expression was analyzed by TMA. The data of primary tumor staging, age, estrogen receptor status, lymph node status, histological grading and TNM staging were also collected.
Results:
There were 40 patients (41%) with 0-1 expression of IGFBP-3, 52 patients (54%) with 2 expression of IGFBP-3 and 5 patients (5%) with 3 expression in IGFBP-3. By multivariate analysis, the IGFBP-3 expression turned out to be significantly related to the overall five-year survival rate.
Conclusion:
The preliminary results about IGFBP-3 expression in breast cancer are intriguing and require further evaluation.
