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Controlled release from cylindrical microstructures.

R Price¹, M Patchan

¹Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC.

Journal of Microencapsulation

|July 1, 1991

Summary

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Metal-coated lipid microtubules encapsulate and control the release of tetracycline and epoxy materials. These rugged tubules offer a novel drug delivery system with tunable release kinetics in various environments.

Area of Science:

Materials Science
Biotechnology
Drug Delivery

Background:

Diacetylenic phosphatidyl-choline microtubules offer potential for material encapsulation.
Metal deposition enhances microtubule durability and solvent resistance.

Purpose of the Study:

To encapsulate a mixture of tetracycline and epoxy monomers/polymers within metal-coated microtubules.
To investigate the in vitro release kinetics of encapsulated materials in dynamic and static environments.

Main Methods:

Electroless metal deposition on diacetylenic phosphatidyl-choline microtubules.
Encapsulation of tetracycline, epoxy monomers, and polymers.
In vitro release studies in dynamic and static conditions.

Main Results:

Related Experiment Videos

Successful encapsulation of tetracycline and epoxy components within metal-coated microtubules.
Demonstrated controlled release of encapsulated materials.
Characterization of release kinetics in different environmental conditions.

Conclusions:

Metal-coated lipid microtubules are a viable system for encapsulating and controlling the release of diverse materials.
This technology shows promise for applications in drug delivery and material science.
Tunable release kinetics can be achieved by controlling environmental factors.