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07:27
Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
Published on: December 18, 2012
Ocular manifestations associated with murine typhus.
M Khairallah1, S Ben Yahia, A Toumi
1Department of Ophthalmology, Fattouma Bourguiba University Hospital, 5019, Monastir, Tunisia. moncef.khairallah@rns.tn
The British Journal of Ophthalmology
|May 6, 2009
Summary
Ocular manifestations are common in acute murine typhus (MT), affecting nearly 90% of patients. Early ophthalmic examination aids in diagnosing this Rickettsia typhi infection.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Microbiology
Background:
- Murine typhus (MT), caused by Rickettsia typhi, is an infectious disease.
- Ocular manifestations of MT are not well-characterized.
Purpose of the Study:
- To characterize and analyze ocular manifestations in patients with acute MT.
- To evaluate the utility of ophthalmic examinations in diagnosing MT.
Main Methods:
- Prospective study of nine patients with serologically confirmed acute MT.
- Comprehensive ophthalmic examinations including fundus photography and angiography (FA, ICG).
Main Results:
- 88.9% of patients exhibited bilateral ocular involvement.
- Common findings included vitreous inflammation, retinal lesions/hemorrhages, vascular leakage, and optic disc abnormalities.
- Hypofluorescent choroidal dots were observed in 61.1% of eyes on angiography.
Conclusions:
- Ocular involvement is frequent in acute MT.
- Ophthalmic examination, especially with angiography, can aid in early MT diagnosis.
- Ocular findings were self-limited.
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