Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Internal Anatomy of the Kidney01:12

Internal Anatomy of the Kidney

The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration01:29

Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration

The kidneys are vital organs responsible for regulating blood filtration, waste excretion, and fluid balance, all of which are crucial for maintaining homeostasis. Renal physiology examines renal blood flow, glomerular filtration, and urine formation, ensuring the body’s internal environment remains stable.Renal Blood FlowThe kidneys receive about 20-25% of the cardiac output, typically around 1200 mL of blood per minute in an average adult. Blood flows into the kidneys through the renal...
External Anatomy of the Kidney01:21

External Anatomy of the Kidney

The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
Physiology of the Genitourinary System II: Tubular Reabsorption and Secretion01:22

Physiology of the Genitourinary System II: Tubular Reabsorption and Secretion

The kidneys maintain homeostasis through filtration, reabsorption, and secretion. Tubular reabsorption and secretion are crucial in forming urine and regulating electrolytes, water balance, and waste elimination.Tubular Reabsorption and Secretion ProcessesTubular reabsorption is the process that reclaims essential substances such as electrolytes, glucose, amino acids, and water from the glomerular filtrate back into the bloodstream. This is achieved through passive and active transport...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative Adsorption Behavior of Orange Peel Powder and Its Chars for Dye Removal.

ACS omega·2026
Same author

Self-Reported Seizure Durations.

JAMA neurology·2026
Same author

A hybrid framework for compartmental models enabling simulation-based inference.

Journal of mathematical biology·2026
Same author

Imaging skins: stretchable Gd2O2S:Tb X-ray detectors for image-guided surgery.

International journal of computer assisted radiology and surgery·2026
Same author

Transcatheter Tricuspid Valve Replacement Reduces Heart Failure Hospitalization: Insights From the Canadian Evoque Registry.

The Canadian journal of cardiology·2026
Same author

Ensemble forecasts of COVID-19 activity to support Australia's pandemic response: 2020-22.

PLoS computational biology·2026

Related Experiment Video

Updated: Jun 23, 2026

Efficient Vascularization of Kidney Organoids through Intracelomic Transplantation in Chicken Embryos
07:35

Efficient Vascularization of Kidney Organoids through Intracelomic Transplantation in Chicken Embryos

Published on: February 17, 2023

A computational model for emergent dynamics in the kidney.

Robert Moss1, Ed Kazmierczak, Michael Kirley

  • 1Department of Computer Science and Software Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia.

Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
|May 6, 2009
PubMed
Summary

This study models kidney nephron networks to understand how individual nephron variability leads to overall kidney stability. The network model explains how kidneys maintain stable blood solute levels despite nephron damage or chaotic behavior.

More Related Videos

In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow
10:25

In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow

Published on: February 4, 2015

Modeling Hypoxia/Reoxygenation Injury in Proximal Tubular Epithelial Cells
06:23

Modeling Hypoxia/Reoxygenation Injury in Proximal Tubular Epithelial Cells

Published on: November 21, 2025

Related Experiment Videos

Last Updated: Jun 23, 2026

Efficient Vascularization of Kidney Organoids through Intracelomic Transplantation in Chicken Embryos
07:35

Efficient Vascularization of Kidney Organoids through Intracelomic Transplantation in Chicken Embryos

Published on: February 17, 2023

In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow
10:25

In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow

Published on: February 4, 2015

Modeling Hypoxia/Reoxygenation Injury in Proximal Tubular Epithelial Cells
06:23

Modeling Hypoxia/Reoxygenation Injury in Proximal Tubular Epithelial Cells

Published on: November 21, 2025

Area of Science:

  • Computational Biology
  • Physiology
  • Network Science

Background:

  • Kidney function relies on nephrons, the basic functional units.
  • Individual nephron behavior can be highly variable and even chaotic.
  • Despite this, the kidney maintains remarkable overall stability in blood solute levels.

Purpose of the Study:

  • To model complex biological systems, specifically kidney nephron networks.
  • To investigate the stability and dynamics of systems of nephrons.
  • To explore the mechanisms underlying kidney stability and solute regulation.

Main Methods:

  • Adapted and extended network automata concepts to model nephron systems.
  • Developed a network model incorporating tubuloglomerular feedback and nephron coupling.
  • Simulated systems with varying numbers of nephrons (2, 8, and 72).
  • Explored effects of changes in hydrostatic pressure, osmotic pressure, and ion concentrations (sodium, chloride).

Main Results:

  • The network model demonstrates how coupled nephron interactions lead to system stability.
  • Simulations revealed the development of stable ionic and osmotic gradients crucial for the countercurrent exchange mechanism.
  • The model successfully reproduced observed oscillations in single nephron filtration rates.
  • Investigated the impact of parameter changes on kidney system dynamics.

Conclusions:

  • Network modeling provides a powerful framework for understanding complex biological systems like the kidney.
  • Coupled nephron interactions are key to maintaining kidney stability and homeostasis.
  • The model elucidates mechanisms for stable solute levels and countercurrent exchange, even with nephron damage.