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Related Concept Videos

Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Nursing Clinical Information System01:27

Nursing Clinical Information System

Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
Imaging Studies I: Kidney, Ureter, and Bladder Studies01:28

Imaging Studies I: Kidney, Ureter, and Bladder Studies

Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...
Renal Tubule and Collecting Duct01:24

Renal Tubule and Collecting Duct

The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Hepatic Portal System01:21

Hepatic Portal System

The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is responsible...
Portal Hypertension01:22

Portal Hypertension

Portal hypertension is an increase in blood pressure within the portal venous system. Normally, this pressure is less than 5 mmHg. It is considered clinically significant when it rises above 10 mmHg. At this threshold, complications from altered blood flow and venous congestion emerge.EtiologyPortal hypertension arises from conditions that impede blood flow through the liver. The most common cause is cirrhosis, in which chronic liver injury leads to fibrotic scarring. This fibrosis narrows or...

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Related Experiment Video

Updated: Jun 23, 2026

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

The Virtual Kidney: an eScience interface and Grid portal.

Peter J Harris1, Rajkumar Buyya, Xingchen Chu

  • 1Faculty Information Technology Unit, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Victoria 3010, Australia. pjharris@unimelb.edu.au

Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
|May 6, 2009
PubMed
Summary

The Virtual Kidney platform offers scientists remote access to kidney simulations and data. This computational tool enhances collaborative research by integrating models, literature, and experimental designs.

Related Experiment Videos

Last Updated: Jun 23, 2026

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

Area of Science:

  • Nephrology
  • Computational Biology
  • Bioinformatics

Background:

  • Accessing complex computational simulations and distributed knowledge databases across geographically separated labs is challenging for experimental scientists.
  • Integrating published literature, databases, theoretical models, and experimental design formulation requires specialized environments.

Purpose of the Study:

  • To develop a web-based platform, the Virtual Kidney, enabling seamless access to computational simulations and knowledge databases for researchers.
  • To facilitate collaborative research by leveraging high-bandwidth networks for shared access to resources.
  • To create a transferable research tool applicable to various scientific fields requiring integration of diverse data and models.

Main Methods:

  • Utilized a web interface and distributed computing for accessing simulations and databases.
  • Developed a web-based three-dimensional interface for experimental data, parameter database, and mathematical models.
  • Implemented a Grid resource broker for managing scheduling, monitoring, and visualization of simulation results and resource allocation.
  • Created a multi-scale kidney reconstruction with linked databases for parameters and literature extracts.

Main Results:

  • Users can explore complex models without needing specific programming environments.
  • Simulation results are visualized graphically or as scaled color gradients on Virtual Kidney structures.
  • The platform allows for visual and quantitative appreciation of simulated parameter changes' effects.

Conclusions:

  • The Virtual Kidney provides an accessible platform for computational simulations and knowledge resources in renal science.
  • The system's design is transferable to other research areas needing to integrate literature, databases, models, and experimental design.
  • Facilitates collaborative research and shared access to scientific knowledge and computational tools.