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Updated: Jun 23, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Coupling contraction, excitation, ventricular and coronary blood flow across scale and physics in the heart
Jack Lee1, Steven Niederer, David Nordsletten
1Oxford University Computing Laboratory, University of Oxford, Wolfson Building, Parks Road, Oxford OX1 3QD, UK.
Abstract:
In this study, we review the development and application of multi-physics and multi-scale coupling in the construction of whole-heart physiological models. Through an examination of recent computational modelling developments, we analyse the significance of coupling mechanisms for the increased understanding of cardiac function in the areas of excitation-contraction, coronary blood flow and ventricular fluid mechanical coupling. Within these physiological domains, we demonstrate and discuss the importance of model parametrization, imaging-based model anatomy and computational implementation.
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