Related Experiment Video
Updated: Jun 23, 2026

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
Published on: March 22, 2012
Fatal Aspergillus rhinosinusitis during induction chemotherapy in a child with acute lymphoblastic leukemia
Hester Vlaardingerbroek1, Michiel van der Flier, Johannes A Borgstein
1Department of Pediatrics, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands. h.vlaardingerbroek@erasmusmc.nl
Abstract:
Invasive fungal infections are a major problem in patients treated for hematologic malignancies. We report a 3-year-old girl who suffered from febrile neutropenia during induction therapy for acute lymphoblastic leukemia. Initial chest computed tomography revealed no evidence of intrapulmonary fungal lesions, however, plasma galactomannan ratio was positive. Aspergillus flavus was cultured from nasal swab and endoscopic biopsy confirmed Aspergillus rhinosinusitis. After an initially good response to voriconazole and extensive debridement, she developed late intracranial hemorrhage and infarction with fatal outcome. This case stresses the importance of early suspicion and aggressive treatment of Aspergillus rhinosinusitis in patients with febrile neutropenia.
Related Concept Videos
Cryptococcal Meningitis
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
