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Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Osteoclasts in Bone Remodeling

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

Hormones and Bone Tissue

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...

Role of Vitamins in Maintaining Bone Health

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...

Essential Minerals for Bone Health

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...

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Related Experiment Video

Updated: Jun 23, 2026

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

Osteoporosis in china.

Y Wang¹, Y Tao, M E Hyman

¹Center for Human Nutrition, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA. ywang@jhsph.edu

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA

|May 6, 2009

Summary

This summary is machine-generated.

Osteoporosis prevalence in China, Hong Kong, and Taiwan is low compared to Caucasian populations, with mainland China showing approximately 13% prevalence. Further monitoring is recommended for national health programs.

Related Experiment Videos

Last Updated: Jun 23, 2026

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

Area of Science:

Public Health
Epidemiology
Gerontology

Background:

Osteoporosis is a growing global health concern, particularly in aging populations.
Limited data exists on osteoporosis prevalence in developing nations like China.
Aging demographics and lifestyle shifts in China may increase osteoporosis risk.

Purpose of the Study:

To assess the prevalence and trends of osteoporosis in mainland China, Hong Kong, and Taiwan.
To provide insights into the disease burden of osteoporosis in Chinese populations.

Main Methods:

A comprehensive review of studies published in English and Chinese from 1980 to May 2008.
Analysis of osteoporosis prevalence data across different regions, demographics, and diagnostic criteria.

Main Results:

Osteoporosis prevalence increases with age and varies by diagnostic criteria, region, gender, and bone site.
In mainland China, average osteoporosis prevalence was 13.0% (range 6.6%-19.3%).
Prevalence in Hong Kong (women ≥50) was 34.1%-37% (spine), 7% (men). Taiwan (≥50) showed 11.4% (women) and 1.6% (men).

Conclusions:

Osteoporosis prevalence in Chinese populations is generally lower than in Caucasian populations.
Continued national monitoring is crucial to track osteoporosis burden in China.
Data suggests a need for targeted public health strategies for osteoporosis prevention and management.