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Imaging Biological Samples with Optical Microscopy01:18

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Linking whole-slide microscope images with DICOM by using JPEG2000 interactive protocol.

Vilppu J Tuominen1, Jorma Isola

  • 1Institute of Medical Technology, University of Tampere and Tampere University Hospital, 33014, Tampere, Finland. vilppu.tuominen@uta.fi

Journal of Digital Imaging
|May 6, 2009
PubMed
Summary
This summary is machine-generated.

Digitized histopathologic whole-slide images (WSIs) can now be linked with the Digital Imaging and Communications in Medicine (DICOM) standard using JPEG2000 and JPIP. This overcomes size limitations, enabling efficient storage and transmission of WSIs within PACS.

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Area of Science:

  • Digital Pathology
  • Medical Imaging Standards
  • Health Informatics

Background:

  • Digitized histopathologic specimens, or whole-slide images (WSIs), are crucial for clinical medicine but face compatibility issues with the Digital Imaging and Communications in Medicine (DICOM) standard.
  • WSIs often exceed the DICOM image object size limit, hindering straightforward storage and exchange. Transmitting entire DICOM images for WSI viewing is also inefficient.

Purpose of the Study:

  • To explore the feasibility of using the JPEG2000 Interactive Protocol (JPIP) to link JPEG2000 WSIs with a DICOM-based Picture Archiving and Communications System (PACS).
  • To develop a proof-of-concept DICOM client-server system capable of transmitting patient data, conventional DICOM imagery, and JPIP-linked JPEG2000 WSIs.

Main Methods:

  • Modified an open-source DICOM library to support JPIP, adhering to DICOM Supplement 106.
  • Developed a software package, JVSdicom, comprising a compressor, PACS server, and PACS client for transmitting JPIP-linked WSIs and other DICOM data.
  • Utilized JPEG2000 compression for WSIs to ensure DICOM compatibility.

Main Results:

  • Demonstrated that JPEG2000 and JPIP offer a functional solution for linking WSIs with DICOM.
  • The JVSdicom software package successfully transmits patient data, radiological images, and JPIP-linked JPEG2000 WSIs.
  • The solution requires only minor modifications to the current DICOM standard specifications.

Conclusions:

  • JPEG2000 and JPIP provide an effective method for integrating whole-slide images into DICOM-based PACS.
  • The developed JVSdicom system proves the viability of this approach for clinical applications.
  • Minor adjustments to the DICOM standard are sufficient to enable seamless WSI integration.