Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of Data in Development and Application of Quantitative Systems Pharmacology Models.

Handbook of experimental pharmacology·2025
Same author

Identification of oncology pharmacokinetic drivers through in vitro experiments and computational modeling.

Journal of pharmacokinetics and pharmacodynamics·2025
Same author

Quantitative systems toxicology modeling in pharmaceutical research and development: An industry-wide survey and selected case study examples.

CPT: pharmacometrics & systems pharmacology·2024
Same author

Volumetric imaging of optically cleared and fluorescently labeled animal tissue (VIOLA) for quantifying the 3D biodistribution of nanoparticles at cellular resolution in tumor tissue.

Journal of controlled release : official journal of the Controlled Release Society·2023
Same author

Roadmap on plasticity and epigenetics in cancer.

Physical biology·2022
Same author

Estimation of Tidal Volume Using Load Cells on a Hospital Bed.

IEEE journal of biomedical and health informatics·2022

Related Experiment Video

Updated: Jun 23, 2026

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance
14:01

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Published on: July 22, 2011

A review of imaging agent development.

Eric D Agdeppa1, Mary E Spilker

  • 1Medical, Science, and Technology Office, GE Healthcare, 101 Carnegie Center, Princeton, New Jersey 08540, USA.

The AAPS Journal
|May 6, 2009
PubMed
Summary

Developing new diagnostic imaging agents like positron emission tomography (PET) and single-photon emission computed tomography (SPECT) tracers involves unique challenges and opportunities. Partnerships can accelerate the clinical translation of these vital imaging agents.

More Related Videos

Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice
07:45

Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice

Published on: October 25, 2024

Related Experiment Videos

Last Updated: Jun 23, 2026

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance
14:01

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Published on: July 22, 2011

Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice
07:45

Preclinical Positron Emission Tomography with Body Conforming Animal Molds for Cloud-Based Automated Image Analysis in Mice

Published on: October 25, 2024

Area of Science:

  • Nuclear medicine and molecular imaging.
  • Radiopharmaceutical chemistry and development.
  • Translational research in diagnostics.

Background:

  • The discovery and development of imaging agents, particularly positron emission tomography (PET) and single-photon emission computed tomography (SPECT) tracers, are crucial for medical diagnostics.
  • While sharing similarities with drug development, imaging agent creation requires specific criteria for target selection and imageability.
  • Preclinical imaging serves as a vital translational tool for validating mechanisms and concepts before clinical application.

Purpose of the Study:

  • To provide an educational review of the processes, opportunities, and challenges in discovering and developing novel imaging agents.
  • To highlight the unique considerations for imaging agent development compared to traditional pharmaceuticals.
  • To discuss strategies for overcoming bottlenecks and accelerating the clinical translation of imaging tracers.

Main Methods:

  • Review of existing literature and industry practices in imaging agent development.
  • Analysis of the parallel processes and unique requirements in drug versus imaging agent discovery.
  • Discussion of market, intellectual property, radiolabeling, and target concentration challenges.

Main Results:

  • Imaging agent development allows targeting of functional or non-functional disease-related targets if they meet imageability criteria.
  • Key challenges include small market sizes, intellectual property hurdles, radiolabeling limitations, and achieving adequate target concentrations.
  • Collaborative approaches, such as microdosing and theranostics, show promise in accelerating clinical translation.

Conclusions:

  • Successful imaging agent development requires navigating specific scientific, regulatory, and market challenges.
  • Strategic partnerships between pharmaceutical and imaging companies are essential for efficient clinical translation.
  • Continued innovation in imaging agents, supported by preclinical research and collaborative models, is vital for advancing medical diagnostics.