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Related Experiment Video

Updated: Jun 23, 2026

Engineered Vascularized Muscle Flap
08:18

Engineered Vascularized Muscle Flap

Published on: January 11, 2016

Soft tissue augmentation with ArteFill.

John M Hilinski1, Steven R Cohen

  • 1San Diego Face and Neck Specialties, San Diego, California 92103, USA. info@drhilinski.com

Facial Plastic Surgery : FPS
|May 6, 2009
PubMed
Summary
This summary is machine-generated.

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ArteFill, a polymethylmethacrylate (PMMA) injectable filler, offers permanent volume enhancement by stimulating collagen. Its improved biocompatibility and uniform microspheres lead to fewer adverse events compared to older fillers.

Area of Science:

  • Dermatology
  • Plastic Surgery
  • Biomaterials Science

Background:

  • ArteFill is a third-generation injectable filler utilizing polymethylmethacrylate (PMMA) microspheres.
  • It is designed for permanent volume augmentation through collagen stimulation.
  • Compared to earlier fillers, ArteFill exhibits enhanced biocompatibility due to uniform microsphere characteristics.

Purpose of the Study:

  • To describe the properties and applications of ArteFill as a novel injectable filler.
  • To highlight its mechanism of action in achieving permanent volume enhancement.
  • To discuss its approved and off-label uses in aesthetic facial procedures.

Main Methods:

  • Review of ArteFill's composition and mechanism of action.
  • Discussion of its FDA approval and common clinical applications.

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  • Emphasis on technique for optimal outcomes and complication management.

    • Main Results:

    • ArteFill provides permanent volume enhancement via fibroblast stimulation and collagen deposition around PMMA microspheres.
    • FDA approved for nasolabial folds, it is also used off-label for tear troughs and marionette lines.
    • Complications, primarily nodule formation, are generally manageable with conservative treatment.

    Conclusions:

    • ArteFill offers a durable solution for facial volume augmentation.
    • Proper technique and conservative application are crucial for successful outcomes.
    • The material's improved biocompatibility contributes to a favorable safety profile.