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Updated: Jun 23, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Tretinoin overdose: a first case report.

Adeline Su-Yin¹, Joyce Wong, Timothy Wiegand

¹Department of Emergency Medicine, Singapore General Hospital, Singapore. angosy@gmail.com

Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology

|May 6, 2009

Summary

This summary is machine-generated.

This case report details the first known instance of a massive oral overdose of tretinoin (Vesanoid). The patient experienced only mild diarrhea, which resolved with treatment, highlighting the generally low toxicity of acute tretinoin overdose.

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Last Updated: Jun 23, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

Pharmacology
Toxicology
Clinical Medicine

Background:

Tretinoin (all-trans-retinoic acid) is a derivative of Vitamin A.
While isotretinoin overdose cases exist, no reports of tretinoin overdose were previously documented.
This study presents the first known case of a massive tretinoin overdose.

Observation:

A 31-year-old male ingested 1000 mg of tretinoin in a suicide attempt.
The patient presented with nonbloody diarrhea as the sole symptom.
Clinical examination and blood results showed no abnormalities; the patient recovered within three days.

Findings:

The ingested dose was approximately three times the recommended maximum tolerated daily dose.
Unlike other retinoids, acute tretinoin overdose in this case resulted in only minor, transient symptoms.
Diarrhea was the only adverse effect, resolving with symptomatic treatment and hydration.

Implications:

This report suggests a potentially lower acute toxicity profile for tretinoin overdose than previously assumed.
The findings provide valuable clinical data for managing future tretinoin overdose incidents.
Further research may be warranted to fully elucidate the toxicological profile of acute tretinoin ingestion.