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A biochip model of lymphocyte locomotion on confined chemokine tracks

Amnon Buxboim1, Erez Geron, Ronen Alon

  • 1Department of Materials and Interfaces, The Weizmann Institute of Science, Rehovot 76100, Israel.

Small (Weinheim an Der Bergstrasse, Germany)
|May 6, 2009
PubMed
Abstract

No abstract available in PubMed .

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Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...

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