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Updated: Jun 23, 2026
09:04
A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
The function of vascular endothelial growth factor.
Bonnie J Nieves1, Patricia A D'Amore, Brad A Bryan
1Ghosh Science and Technology Center, Department of Biology, Worcester State College, Worcester, MA, USA.
Biofactors (Oxford, England)
|May 6, 2009
Summary
Vascular endothelial growth factor (VEGF) is key to blood vessel growth in development and diseases like cancer. This review covers VEGF signaling and anti-angiogenic therapies, including their benefits and side effects.
Area of Science:
- Molecular Biology
- Cell Biology
- Oncology
Background:
- Vascular endothelial growth factor (VEGF) is a critical regulator of angiogenesis.
- Aberrant angiogenesis is implicated in diseases including cancer, diabetes, and macular degeneration.
Purpose of the Study:
- To review the current understanding of VEGF signaling pathways.
- To discuss the therapeutic applications and potential adverse effects of anti-angiogenic treatments.
Main Methods:
- Literature review of scientific publications on VEGF and angiogenesis.
- Analysis of clinical data regarding anti-angiogenic therapies.
Main Results:
- VEGF signaling pathways are complex and multifaceted.
- Anti-angiogenic therapies show promise in inhibiting tumor neovascularization but can have significant side effects.
Conclusions:
- Targeting VEGF signaling is a viable therapeutic strategy for angiogenesis-dependent diseases.
- Careful patient selection and monitoring are crucial for managing side effects of anti-angiogenic drugs.
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