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Updated: Jun 23, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
09:04

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

Published on: March 15, 2016

The function of vascular endothelial growth factor

Bonnie J Nieves1, Patricia A D'Amore, Brad A Bryan

  • 1Ghosh Science and Technology Center, Department of Biology, Worcester State College, Worcester, MA, USA.

Biofactors (Oxford, England)
|May 6, 2009
PubMed

Insights

Vascular endothelial growth factor (VEGF) is key to blood vessel growth in development and diseases like cancer. This review covers VEGF signaling and anti-angiogenic therapies, including their benefits and side effects.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Vascular endothelial growth factor (VEGF) is a critical regulator of angiogenesis.
  • Aberrant angiogenesis is implicated in diseases including cancer, diabetes, and macular degeneration.

Purpose of the Study:

  • To review the current understanding of VEGF signaling pathways.
  • To discuss the therapeutic applications and potential adverse effects of anti-angiogenic treatments.

Main Methods:

  • Literature review of scientific publications on VEGF and angiogenesis.
  • Analysis of clinical data regarding anti-angiogenic therapies.

Main Results:

  • VEGF signaling pathways are complex and multifaceted.
  • Anti-angiogenic therapies show promise in inhibiting tumor neovascularization but can have significant side effects.

Conclusions:

  • Targeting VEGF signaling is a viable therapeutic strategy for angiogenesis-dependent diseases.
  • Careful patient selection and monitoring are crucial for managing side effects of anti-angiogenic drugs.

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