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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Genetic Screens02:46

Genetic Screens

Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Structure of a Gene01:30

Structure of a Gene

A gene is the fundamental unit of heredity. Every individual has two copies of each gene, one inherited from each parent. Although most people contain the same genes, there is a small fraction that is slightly different amongst people. A gene with a small difference in its sequence of DNA bases forms different alleles, contributing to different phenotypes.
However, only 1% of the DNA is composed of genes that encode proteins; the rest, 99% is non-coding DNA. This non-coding DNA performs...
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.

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Related Experiment Video

Updated: Jun 23, 2026

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

Lessons from structural genomics.

Thomas C Terwilliger1, David Stuart, Shigeyuki Yokoyama

  • 1Los Alamos National Laboratory, Los Alamos, NM 87545, USA. terwilliger@lanl.gov

Annual Review of Biophysics
|May 7, 2009
PubMed
Summary
This summary is machine-generated.

Structural genomics projects successfully determined numerous high-quality protein structures annually. Key lessons emphasize technology validation, data sharing, and international collaboration for advancing structural biology.

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Last Updated: Jun 23, 2026

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
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Published on: June 27, 2020

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08:03

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Area of Science:

  • Structural Biology
  • Genomics
  • Biochemistry

Background:

  • Structural genomics has advanced the large-scale determination of protein structures over the past decade.
  • Significant data generation provides valuable insights for structural biology and future large-scale initiatives.

Purpose of the Study:

  • To summarize key lessons learned from a decade of structural genomics.
  • To highlight the impact of technology development and data sharing in protein structure determination.

Main Methods:

  • Large-scale protein structure determination facilities were established and evaluated.
  • Technological advancements and their associated challenges were quantified.
  • Data deposition in public databases and international collaboration were analyzed.

Main Results:

  • Confirmation of the feasibility of producing over a hundred high-quality protein structures annually.
  • Demonstration that technology development and validation are critical for success.
  • Evidence that rapid data sharing and international cooperation enhance impact and progress.

Conclusions:

  • Structural genomics has proven effective in generating substantial, high-quality protein structure data.
  • Continued focus on technological innovation, validation, and open data practices is essential for the field.
  • International collaboration is a vital component for advancing structural biology research.