Related Concept Videos
01:31Transducer Mechanism: Nuclear Receptors
Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
01:30Transducer Mechanism: G Protein–Coupled Receptors
G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical, 7TM, or...
GPCRs are also called heptahelical, 7TM, or...
01:27Feedback Regulation of Calcium Concentration
Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
01:22Hormonal Regulation of the Menstrual Cycle
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
01:21G-protein Coupled Receptors
G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
01:31Internal Receptors
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
You might also read
Related Articles
Articles linked to this work by shared authors, journal, and citation graph.
Sort by
Same author
Broadband unidirectional visible imaging using wafer-scale nano-fabrication of multi-layer diffractive optical processors.
Light, science & applications·2025
Same author
Fertility after treatment of a noncommunicating rudimentary horn pregnancy: A case report.
Case reports in women's health·2022
Same author
Expression of glucocorticoid and androgen receptors in bone marrow-derived hematopoietic and nonhematopoietic murine endometrial cells.
F&S science·2022
Same author
The role of mesenchymal-epithelial transition in endometrial function.
Human reproduction update·2018
Same author
Menstrual Cycle Hormone Changes in Women Traversing Menopause: Study of Women's Health Across the Nation.
The Journal of clinical endocrinology and metabolism·2017
Same author
Recombinant human relaxin versus placebo for cervical ripening: a double-blind randomised trial in pregnant women scheduled for induction of labour.
BMC pregnancy and childbirth·2016
Same journal
Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin-1 in B Cells.
Annals of the New York Academy of Sciences·2026
Same journal
Global Trends in Light Pollution and Their Relationship With Socioeconomic Factors.
Annals of the New York Academy of Sciences·2026
Same journal
Wired for Corruption: Inter-Brain Synchrony Encodes Bribery-Related Value Information and Predicts Bribery Agreement.
Annals of the New York Academy of Sciences·2026
Same journal
LM-YOLO: A Lightweight Multi-Scale Enhanced Model for Forest Smoke Detection Using Unmanned Aerial Vehicles.
Annals of the New York Academy of Sciences·2026
Same journal
Polyrhythm Perception and Production: A Scoping Review.
Annals of the New York Academy of Sciences·2026
Same journal
DARTS-CNN-BiLSTM: Intelligent Fault Diagnosis for Computer Numerical Control Machine Tool Feed System.
Annals of the New York Academy of Sciences·2026
Related Experiment Video
Updated: Jun 23, 2026
08:02
Visualization of Estrogen Receptors in Colons of Mice with TNBS-Induced Crohn's Disease using Immunofluorescence
Published on: March 12, 2020
Relaxin receptor LGR7 (RXFP1) is regulated by estrogen.
Priya Maseelall1, Jeff Gardner, Andrea Wojtczuk
1New Jersey Medical School, Newark, New Jersey 07103, USA.
Annals of the New York Academy of Sciences
|May 7, 2009
Summary
Estradiol, a form of estrogen, increases LGR7 (also known as RXFP1) mRNA expression in human cervix cells. This suggests estradiol may enhance the effects of relaxin during pregnancy.
More Related Videos
09:07Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
Published on: December 19, 2018
09:07Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation
Published on: June 21, 2016
Area of Science:
- Reproductive Endocrinology
- Molecular Biology
- Gynecology
Background:
- Estrogen plays a crucial role in regulating physiological changes during pregnancy.
- Relaxin hormone is vital for cervical ripening and remodeling.
- LGR7 (RXFP1) is a receptor for relaxin, mediating its effects.
Purpose of the Study:
- To investigate the effect of estrogen on LGR7 (RXFP1) mRNA expression in human cervical fibroblasts.
- To determine if estradiol influences the expression of the relaxin receptor in the cervix.
Main Methods:
- Utilized an in vitro model of human term pregnancy cervix.
- Isolated and cultured lower uterine segment fibroblasts.
- Measured LGR7 (RXFP1) mRNA levels following estradiol treatment using quantitative analysis.
Main Results:
- Estradiol significantly increased LGR7 (RXFP1) mRNA levels in cervical fibroblasts.
- Mean LGR7 mRNA levels rose to 152% +/- 5.9% above control levels.
- Demonstrated a dose-dependent or time-dependent effect of estradiol on LGR7 expression (implied).
Conclusions:
- Estrogen, specifically estradiol, upregulates LGR7 (RXFP1) mRNA expression in the human cervix.
- Estradiol may potentiate the actions of relaxin in the cervix by increasing its receptor expression.
- Findings suggest a potential mechanism for hormonal regulation of cervical function during pregnancy.