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Updated: Jun 23, 2026

Visualization of Estrogen Receptors in Colons of Mice with TNBS-Induced Crohn's Disease using Immunofluorescence
Published on: March 12, 2020
Relaxin receptor LGR7 (RXFP1) is regulated by estrogen
Priya Maseelall1, Jeff Gardner, Andrea Wojtczuk
1New Jersey Medical School, Newark, New Jersey 07103, USA.
Abstract:
Estrogen regulates LGR7 (RXFP1) mRNA expression in an in vitro model of human term pregnancy cervix that utilizes lower uterine segment fibroblasts. LGR7 mRNA levels were increased by estradiol to mean levels of 152%+/- 5.9% above those in untreated control cells. Therefore, estradiol may amplify relaxin's actions in the cervix.
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