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Ichthyosiform eruptions in association with primary cutaneous T-cell lymphomas.
S Morizane1, N Setsu, T Yamamoto
1Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
The British Journal of Dermatology
|May 7, 2009
Summary
Ichthyosiform eruptions are linked to specific lymphomas, particularly anaplastic large cell lymphoma (ALCL) and mycosis fungoides (MF). Histopathology helps classify these eruptions into acquired ichthyosis (AI), ichthyosiform mycosis fungoides (IMF), or overlap types.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Malignant lymphomas can manifest with ichthyosiform eruptions.
- Understanding this association is crucial for diagnosis and management.
Purpose of the Study:
- To histopathologically analyze ichthyosiform eruptions in patients with cutaneous lymphomas.
- To differentiate subtypes of these eruptions based on underlying lymphoma.
Main Methods:
- Retrospective review of patient files from January 2001 to May 2006.
- Histopathological examination of skin biopsies from patients with malignant lymphoma and ichthyosiform eruptions.
Main Results:
- Nine out of 106 lymphoma patients presented with ichthyosiform eruptions.
- Anaplastic large cell lymphoma (ALCL) and mycosis fungoides (MF) were frequently associated.
- Eruptions were classified as acquired ichthyosis (AI)-like, ichthyosiform mycosis fungoides (IMF)-like, or overlapping, with distinct histopathological features and filaggrin expression patterns.
Conclusions:
- Ichthyosiform eruptions are significant cutaneous manifestations of ALCL and MF.
- Classification into AI, IMF, and overlap categories aids in understanding their pathogenesis.
- Filaggrin deficiency is a common feature, similar to inherited ichthyosis vulgaris.
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