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Relapsing polychondritis in a child with common variable immunodeficiency
Neslihan Edeer Karaca1, Guzide Aksu, Basak Yildiz
1Department of Pediatrics, Division of Pediatric Immunology, Faculty of Medicine, Ege University, Department of Dermatology, Izmir, Turkey. neslihanedeer@yahoo.com
Abstract:
Common variable immunodeficiency (CVID) is associated with recurrent infections and autoimmunity. The most common autoimmune conditions are idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia, chronic arthritis, and gastrointestinal inflammation. Relapsing polychondritis (RP) is an episodic and progressive systemic inflammatory disease, characterized by auricular chondritis, polyarthritis, nasal, and respiratory tract chondritis. Autoimmunity to cartilage-related components is thought to be involved in its pathogenesis. So far, RP has not been included within many autoimmune conditions that have been reported in patients with either CVID or any other primary immunodeficiency. In this report, a case of CVID with RP and chronic arthritis is presented.
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