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Stimulation of Notch Signaling in Mouse Osteoclast Precursors
Published on: February 28, 2017
Endocytic regulation of notch signalling during development
Maximilian Fürthauer1, Marcos González-Gaitán
1Department of Biochemistry and Molecular Biology, University of Geneva, Sciences II, 30 quai Ernest Ansermet, CH-1211 Geneva 4, Switzerland. Maximilian.Fuerthauer@unige.ch
Traffic (Copenhagen, Denmark)
|May 7, 2009
Summary
Endocytosis is crucial for Delta/Notch signalling, not just signal downregulation. This review explores how endocytic trafficking of Delta and Notch during cell division directs developmental signals, particularly in Drosophila bristle development.
Area of Science:
- Cell Biology
- Developmental Biology
- Molecular Signalling
Background:
- Delta/Notch signalling is vital for embryonic development and adult life.
- Endocytosis plays a key role in activating Notch signalling through ligand and receptor internalization.
- The development of Drosophila mecanosensory bristles serves as a model system for studying Delta/Notch signalling.
Purpose of the Study:
- To review recent findings on the role of endocytosis in Delta/Notch signalling.
- To discuss how differential endocytic trafficking of Delta and Notch directs signalling.
- To explore the function of endosomal compartments as signalling platforms.
Main Methods:
- Review of existing literature and recent evidence.
- Biochemical analysis of endocytic Delta trafficking.
- Studies utilizing Drosophila mecanosensory bristle development as a model.
Main Results:
- Ligand and receptor internalization are essential for Notch activation.
- Differential endocytosis of Delta/Notch occurs in daughter cells after asymmetric division, ensuring directional signalling.
- Multivesicular endosomes contribute to directional Delta/Notch transport during asymmetric cell division.
- Distinct phases of endocytic Delta trafficking have complementary roles in recycling, interaction, and activation.
- Endosomal compartments may function as platforms for Delta/Notch signaling.
Conclusions:
- Endocytosis is integral to the directional activation of Delta/Notch signalling.
- The trafficking of Delta and Notch through endosomes is a complex process with multiple regulatory roles.
- Novel insights into endosomal roles advance the cell biological understanding of Delta/Notch signalling.
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