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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

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Local recurrence of osteosarcoma after 17 years

M J Welck1, P D Gikas, P Pearce

  • 1London Bone and Soft Tissue Tumour Service, Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK.

Annals of the Royal College of Surgeons of England
|May 7, 2009
PubMed

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Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...