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[Percutaneous aortic valve replacement - initial experience and results]
Lene Kjaer Olsen1, Thomas Engstrøm, Kristian Wachtell
1Kardiologisk Klinik B 2014, Rigshospitalet, DK-2100 København Ø.
Ugeskrift for Laeger
|May 7, 2009
Summary
Percutaneous aortic valve replacement offers a promising new treatment for patients with inoperable aortic stenosis (AS). This study shows successful valve implantation with significant symptom relief and improved aortic valve function in a small patient cohort.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Biomedical Engineering
Context:
- Aortic stenosis (AS) is a prevalent valvular heart disease with significant morbidity and mortality.
- Surgical valve replacement is standard for symptomatic AS, but many patients are inoperable.
- Inoperable patients with severe AS require alternative treatment options.
Purpose:
- To evaluate the outcomes of percutaneous aortic valve replacement (PAVR) in patients with inoperable severe AS.
- To assess the safety and efficacy of the CoreValve ReValving System in this patient population.
Summary:
- Twenty inoperable AS patients received the CoreValve prosthesis, achieving 100% procedural success.
- Significant improvements were observed in aortic valve area and pressure gradients post-procedure.
- 30-day mortality was 5%, with permanent pacemaker implantation (25%) being the most frequent complication.
Impact:
- PAVR demonstrates potential as a crucial therapeutic option for inoperable AS patients.
- These findings align with international experiences, suggesting broader applicability.
- The study provides early evidence supporting PAVR's role in managing severe, inoperable aortic stenosis.
