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Updated: Jun 23, 2026

Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting
Published on: October 26, 2018
Rapid modification of retroviruses using lipid conjugates
Nimisha G Mukherjee1, L Andrew Lyon, Joseph M Le Doux
1The Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Atlanta, GA 30332-0535, USA.
Abstract:
Methods are needed to manipulate natural nanoparticles. Viruses are particularly interesting because they can act as therapeutic cellular delivery agents. Here we examine a new method for rapidly modifying retroviruses that uses lipid conjugates composed of a lipid anchor (1,2-distearoyl-sn-glycero-3-phosphoethanolamine), a polyethylene glycol chain, and biotin. The conjugates rapidly and stably modified retroviruses and enabled them to bind streptavidin. The implication of this work for modifying viruses for gene therapy and vaccination protocols is discussed.
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